New Product
Pasthil.
Pasthil is a line of herbal lozenges (pastilles) produced by Leda Pharma (Leda İlaç), a pharmaceutical company based in Turkey. These products are primarily used to soothe throat irritation, relieve coughs, and support the immune system. They are generally classified as food supplements rather than prescription medications. Here are the key details about Pasthil products: 1. Common Ingredients Depending on the specific variety, Pasthil lozenges typically contain a combination of: Propolis: Known for its natural antibacterial and antiviral properties. Ginger & Turmeric: Used for their anti-inflammatory effects. Vitamin C: To support the immune system. Menthol/Peppermint: To provide a cooling sensation and open the airways. Honey & Lemon: To coat and soothe a dry or scratchy throat. 2. Popular Variants Leda Pharma usually offers several "flavors" or formulations, such as: Pasthil Ginger & Lemon: Focuses on refreshing the throat and reducing nausea or irritation. Pasthil Propolis: Aimed at stronger immune support and treating more painful throat conditions. Pasthil Orange: Often packed with extra Vitamin C. 3. What is it used for? Sore Throat: Relieving pain and scratchiness. Hoarseness: Helping to clear the voice. Cough Relief: Suppressing the urge to cough by keeping the throat moist. Mouth Hygiene: Refreshing the breath and providing mild antiseptic benefits. 4. How to Use Dosage: Usually, it is recommended to dissolve one lozenge slowly in the mouth every 2–3 hours. Caution: Because they often contain sugar or sweeteners, people with diabetes should check the specific packaging. They are generally not recommended for very young children due to the risk of choking.
Deflux® (Domperidone) 5mg Suspension BP (100ml)
Indications of Deflux 100 ml
Delayed stomach emptying, gastroesophageal reflux, and esophagitis are all symptoms of dyspeptic symptom complex.
Upper abdominal pain, feeling of abdominal distension, and epigastric fullness
Eructation, flatulence, and early satiety are all symptoms of early satiety.
Vomiting and nausea
Regurgitation of stomach contents into the mouth, with or without heartburn
Dyspepsia without ulcers
Acute nausea and vomiting of functional, organic, infectious, or dietetic origin, as well as nausea and vomiting generated by radiotherapy or pharmacological therapy, and nausea and vomiting induced in migraine.
Pharmaceutical Name of Deflux 100 ml
Beximco Pharmaceuticals Ltd.
Pharmacology
Domperidone is a dopamine agonist that works by blocking dopamine receptors in the chemoreceptor trigger Zone (CTZ) in the stomach. Its gastroprokinetic function is based on the inhibition of dopamine receptors in the gastrointestinal tract, which impact motility. Domperidone has essentially no effect on dopaminergic receptors in the brain due to its poor penetration across the blood-brain barrier, hence avoiding psychotropic and neurologic adverse effects. Domperidone restores normal upper gastrointestinal motility and tone, aids stomach emptying, improves antral and duodenal peristalsis, and modulates pylorus contraction. Domperid.
Dosage & Administration
Domperidone should be taken 15-30 minutes before meals and, if necessary, before retiring.
The usual recommended oral dose of Domperidone is as follows:
Adults: 10-20 mg (1-2 tablet or 10-20 ml suspension), every 6-8 hours daily. The maximum dose of Domperidone is 80 mg daily.
Children: 2-4 ml suspension/10 kg body weight or 0.4-0.8 ml paediatric drops/10 kg body weight, every 6-8 hours daily.
In dyspeptic symptom:
Adults: 10-20 mg (1-2 tablet or 10-20 ml suspension), every 6-8 hours daily.
Children: 0.2-0.4 mg/kg (2-4 ml suspension/10 kg or 0.4-0.8 ml paediatric drops/10 kg) body weight, every 6-8 hours daily.
In acute and sub-acute conditions (mainly in acute nausea and vomiting):
Adults: 20 mg (2 tablets or 20 ml suspension), every 6-8 hours daily
Children: 0.2-0.4 mg/kg (2-4 ml suspension/10 kg or 0.4-0.8 ml paediatric drops/10 kg) body weight, every 6-8 hours daily. (In acute nausea and vomiting maximum period of treatment is 12 weeks).
By rectum in suppositories:
Adults (including elderly): 30-60 mg every 4-8 hours.
Children: The maximum daily dose rectally in children's is 30 mg for those weighting 10 to 25 kg. The dose may be divided throughout day if necessary.
The maximum period of treatment is 12 weeks.
Interaction of Deflux 100 ml
Bromocriptine's hypoprolactemic impact may be reduced by domperidone. Antimuscarinics and opoid analgesics may counteract Domperidone's effect on Gl function. When domperidone is used with MAO (monoamine oxidase) inhibitors, caution should be exercised.
Contraindications
Domperidone is a dopamine agonist that works by blocking dopamine receptors in the chemoreceptor trigger Zone (CTZ) in the stomach. Its gastroprokinetic function is based on the inhibition of dopamine receptors in the gastrointestinal tract, which impact motility. Domperidone has essentially no effect on dopaminergic receptors in the brain due to its poor penetration across the blood-brain barrier, hence avoiding psychotropic and neurologic adverse effects. Domperidone restores normal upper gastrointestinal motility and tone, aids stomach emptying, improves antral and duodenal peristalsis, and modulates pylorus contraction.
Side Effects of Deflux 100 ml
Domperidone may produce hyperprolactinemia (1.3%).This may result in galactorrhea, breast enlargement, and soreness and reduced libido. Dry mouth (1%), thirst, headache (1.2%), nervousness, drowsiness (0.4%), diarrhea (0.2%), skin rash and itching (0.1%) may occur during treatment with domperidone. Extra-pyramidal reactions are seen in 0.05% of patients in clinical studies.
Pregnancy & Lactation
The safety of domperidone has not been proven and it is therefore not recommended during pregnancy. Animal studies have not demonstrated the teratogenic effect in the fetus. Domperidone may precipitate galactorrhea and improve post-natal lactation. It is secreted in breast milk but in very small quantities insufficient to be considered harmful.
Precautions & Warnings
Domperidone should be used with absolute caution in the case of children because there may be an increased risk of extrapyramidal reactions in young children because of an incompletely developed blood-brain barrier. Since domperidone is highly metabolized in liver, it should be used with caution in patient with hepatic impairment.
Therapeutic Class
Motility Stimulants, Motility stimulants/Dopamine antagonist, Prokinetic drugs