New Product
Pasthil.
Pasthil is a line of herbal lozenges (pastilles) produced by Leda Pharma (Leda İlaç), a pharmaceutical company based in Turkey. These products are primarily used to soothe throat irritation, relieve coughs, and support the immune system. They are generally classified as food supplements rather than prescription medications. Here are the key details about Pasthil products: 1. Common Ingredients Depending on the specific variety, Pasthil lozenges typically contain a combination of: Propolis: Known for its natural antibacterial and antiviral properties. Ginger & Turmeric: Used for their anti-inflammatory effects. Vitamin C: To support the immune system. Menthol/Peppermint: To provide a cooling sensation and open the airways. Honey & Lemon: To coat and soothe a dry or scratchy throat. 2. Popular Variants Leda Pharma usually offers several "flavors" or formulations, such as: Pasthil Ginger & Lemon: Focuses on refreshing the throat and reducing nausea or irritation. Pasthil Propolis: Aimed at stronger immune support and treating more painful throat conditions. Pasthil Orange: Often packed with extra Vitamin C. 3. What is it used for? Sore Throat: Relieving pain and scratchiness. Hoarseness: Helping to clear the voice. Cough Relief: Suppressing the urge to cough by keeping the throat moist. Mouth Hygiene: Refreshing the breath and providing mild antiseptic benefits. 4. How to Use Dosage: Usually, it is recommended to dissolve one lozenge slowly in the mouth every 2–3 hours. Caution: Because they often contain sugar or sweeteners, people with diabetes should check the specific packaging. They are generally not recommended for very young children due to the risk of choking.
Megatrim®(trimethoprim) 40mg + (Sulfamethoxazole) 200mg Syrup 60ml
Generic
Sulphamethoxazole + Trimethoprim
Indications
In vitro, cotrimoxazole is bactericidal against a wide range of Gram-positive and Gram-negative bacteria, including Streptococcus, Staphylococcus, Pneumococcus, Neisseria, B. catarrhalis, Escherichia coli, Klebsiella, Proteus spp., Haemophilus, Salmonella, Shigella, Vibrio cholerae, Bruce Cotrimoxazole has a high level of activity against Haemophilus influenzae, E. coli, and Proteus spp., which makes it ideal for the treatment of chronic bronchitis and urinary tract infections. Cotrimoxazole works by blocking two bacterial enzyme systems involved in the manufacture of Folinic acid in a sequential manner.
Respiratory tract infections, such as acute and chronic bronchitis (treatment and prophylaxis), bronchiectasis, lung abscess, lobar and bronchopneumonia, Pneumocystis carinii pneumonitis, sinusitis, and otitis media are among the indications.
Urethritis, acute and chronic cystitis, pyelonephritis, prostatitis, and gonorrhoea are examples of genito-urinary tract infections.
Infections of the gastrointestinal system caused by Salmonella typhi and Salmonella paratyphi, as well as the chronic carrier condition.
Other infections caused by a wide range of organisms that have been confirmed to be susceptible to Cotrimoxazole, and for which the therapeutic benefits are thought to outweigh the risk of side effects.
Pharmacology
Cotrimoxazole has broad bactericidal activity against gram-positive and gram-negative bacteria, as well as some protozoa. The bactericidal activity of Co-trimoxazole, which contains Trimethoprim and Sulphamethoxazole in a 1:5 ratio, is mediated by the successive inhibition of two bacterial enzyme systems involved in the manufacture of folinic acid in the bacterium.
Dosage & Administration
Cotrimoxazole double strength tablet: Over 12 years
For mild to moderate infections: 1 tablet twice daily.
For severe infections: 1.5 tablets twice daily.
Long term therapy (>14 days): 0.5 tablet twice daily.
Gonorrhoea: 2 tablets every 12 hours for two days or 2.5 tablets followed by a further dose of 2.5 tablets after 8 hours.
Cotrimoxazole tablet: over 12 years
For mild to moderate infections: 2 tablets twice daily.
For severe infections: 2 tablets thrice daily.
Long term therapy: (>14 days): 1 tablet twice daily.
Cotrimoxazole suspension: Under 12 years
6-12 years: 2 teaspoonful twice daily.
6 month-5 years: 1 teaspoonful twice daily.
6 weeks-6 months: 0.5 teaspoonful twice daily.
Contraindications
Trimethoprim or sulphonamide hypersensitivity.
Patients who have been diagnosed with megaloblastic anemia as a result of a folate deficit.
Patients with significant parenchymal damage to the liver, blood dyscrasia, severe renal failure, and glucose 6-phosphate dehydrogenase deficiency.
Side Effects
Crystalluria, allergic responses, haemolysis, thrombocytopenia, neutropenia, agranulocytosis, and other adverse effects have been described seldom with the combination of Sulphamethoxazole and Trimethoprim. Malaise, headache, nausea, and vomiting are some of the less serious side effects. These are usually transitory and do not need treatment discontinuation.
Pregnancy & Lactation
Pregnancy and during the nursing period, because sulphonamides pass the placenta and are excreted in the breast milk and may cause kernicterus.
Precautions & Warnings
Because the medicine interferes with the conversion of Folic acid to Folinic acid, prolonged full-dose treatment with the sulfamethoxazole-trimethoprim combination increases the risk of macrocytic anemia. Folinic acid can be given to reverse this if it happens. When delivering this combination to diabetic patients on a sulphonylurea treatment, it's important to keep in mind that the sulphonylurea's action may be potentiated.
Therapeutic Class
Anti-diarrhoeal Antimicrobial drugs, Sulphonamides & Trimethoprim